Education:

Massachusetts Institutes of
Technology
1979 - 1983: Ph.D. Organic
Chemistry (Advisor: Prof. S.
Masamune)
Thesis: Stereocontrolled
Synthesis of 1, 2 - and 1, 3 -
Polyhydroxylated Systems.

University of Pennsylvania
1976 - 1979: B.S. Chemistry
(Advisor: Prof. K. C. Nicolaou)

Professional Experience:

Synica USA, Inc.
2002 – Present: President and
Founder

SAR LifeSciences, Inc.
2002 – Present: President and
Founder

DuPont Pharmaceuticals
Company (formally DuPont Merck
Pharmaceuticals Company)
1994 – 2001: Director. Chemical
Process R&D
1993:   Associate Director.
Chemical Process R&D and
Chemical Sciences (Kilo
Lab).
1991 - 1992: Research Manager.
Chemical Sciences R&D (Kilo
Lab and
Thrombin Inhibitor Group Leader)
and Chemical Process R&D.

Du Pont Company
(Pharmaceuticals Division)
1989 - 1990: Group Leader.
Medicinal Chemistry.  
1983 - 1988: Research Chemist.
Medicinal Chemistry.

Publication:

A. E. Sigmund, K. C. McNulty, D.
Nguyen, C. E. Silverman, J. A.
Pesti, P. Ma, and R. DiCosimo,
Can. J. Chem., 2002, 80, 608,
“Enantioselective Enzymatic
Aminolysis of a Racemic 2-
Isoxazolylacetate Alkyl Ester.”

L. Storace, L. Anzalone, P. N.
Confalone, W. P. Davis, J. M.
Fortunak, M. Giangiotdano, K.
Kamholz, H. Li, P. Ma, W. A.
Nugent, R. L. Parsons, P. J.
Sheeran, C. E. Silverman, R. E.
Waltermire, Organic Process
Research & Development, 2002,
6, 54, “An Efficient Large Scale
Process for the Human Leukocyte
Elastase Inhibitor, DMP 777.”

A. J. Robinson, C. Y. Lim, L. He,
P. Ma, H. Li, J. Org. Chem., 2001,
66, 4141, “Highly Enantioselective
Synthesis of a, b-
Diaminopropanoic Acid
Derivatives using a Catalytic
Asymmetric Hydrogenation
Approach.”

R. DiCosimo, P. Ma, J. A. Pesti,
10/039972, US Patent filed Oct.,
2001, “Enantioselective
Enzymatic Aminolysis of a
Racemic 2-Isoxazolylacetate Alkyl
Ester.”

J. Zhou, L. Oh, P. N. Confalone, H.
Li, P. Ma, WO2001029006, April,
2001, “Synthesis of 1,3,5-
Trisubsituted Pyrazoles”

J. Zhou, P. N. Confalone, H. Li, P.
Ma, L. Oh, L. Rossano, PH7113-
P1, US Patent filed 7/26/00,
“Efficient Ligand-mediated
Ullman Coupling of Anilines and
Azoles”

J. Zhou, L. M. Oh, P. Ma,
US6107508, Aug., 2000,
“Convergent synthesis of a-Aryl-b-
Ketonitriles.”

Philip Ma, Biao Jiang,
US5973185, Oct., 1999, “Method
for preparing a-chloroboronic
acids from mannitol.”

P. Ma, P. N. Confalone, H. Y. Li,
US5962693, Oct., 1999, "An
Efficient Method for the
Conversion of Nitriles to
Amidines and Species Thereof.”

Z. G. Li, R. L. Harlow, C. M. Foris,
H. Li, P. Ma, R. D. Vickery, M. B.
Maurin, B. H. Toby, J. of Pharm.
Sci., 1999, 88, 297, “Polymorph
Determination for the GP IIb/IIIa
Antagonist, Roxifiban, Using a
Combination of Electron
Diffraction and Synchrotron X-ray
Powder Diffraction Techniques.”

R. C. Williams, C. M. Riley, K. W.
Sigvardson, J. Fortunak, P. Ma, E.
C. Nicolas, S. E. Unger, D. F.
Krahn, S. L. Brenner J. of Pharm.
&  Biomed. Anal., 1998, 17, 917,
“Pharmaceutical Development
and Specification of
Stereoisomers.”

J. Zhou, J. M. Fortunak, L. M. Oh,
L. Storace, P. Ma, Patent
Application DM-        6903-P1,
Filed 1/6/98, "An Efficient
Synthesis of 2,4,7,8-Tetra-
Substituted         Pyrazole (1.5-a)
-1,3,5-Trizines."

M. B. Maurin, P. Ma, D. J. Meloni,
J. A. Pesti, L. T. Rossano, R. K.
Ward, J. Yin, L. Zhang,
WO9857939, Dec., 1998,
“Crystalline roxifiban for the
treatment of platelet aggregation-
mediated diseases.”
   
J. Wityak, T. M. Sielecki, D. J.
Pinto, G. Emmett, J. Y. Sze, J. Liu,
E. A. Tobin, S. Wang, B. Jiang, P.
Ma, S. A. Mousa, R. E. Olson, R.
R. Wexler, J. Med. Chem., 1997,
40, 1292, "The Discovery of
Potent Isoxazoline Glycoprotein
IIb/IIIa Receptor Antagonists."

L. H. Zhang, J. C. Chung, T. D.
Costello, I. Valvis, P. Ma, G. S.
Kauffman, R. Ward, J. Org.
Chem., 1997, 62, 2466, "The
Enantiospecific Synthesis of  
Isoxazoline DMP 754, a RGD
Mimic Platelet GP IIb/IIIa
Antagonist."

L. H. Zhang, L. Anzalone, P. Ma,
G. S. Kauffman, L. Storace, R.
Ward, Tetra.         Lett., 1996, 37,
4455, "The Chiral Specific
Synthesis of DMP 754, a Platelet  
GP         IIb/IIIa Antagonist."

L. H. Zhang, J. A. Pesti, T. D.
Costello, P. J. Sheeran, R. Uyeda,
P. Ma, G. S.         Kauffman, R.
Ward, J. L. McMillan, J. Org.
Chem., 1996, 61, 5180, "An
Efficient         and Chiral Specific
Synthesis of Cyclic RGD Peptides
as Antithrombotic Agents."

J. Wityak, R. A. Earl, M. M.
Abelman, Y. B. Bethel, B. N.
Fisher, G. S.        Kauffman, C. A.
Kettner, P. Ma, J. L. Mcmillan, L. J.
Mersinger, J. Pesti, M. E,         
Pierce, F. W. Rankin, R. J.
Chorvat, P. N. Confalone J. Org.
Chem., 1995, 60,         3717,
"Synthesis of Thrombin Inhibitor
DuP 714."

L. H. Zhang, W. Meier, E. Wats, T.
D. Costello, P. Ma, C. L. Ensinger,
J. M.         Rodgers, I. C.
Jacobson, P. Rajagopalan, Tetra.
Lett., 1995, 46, 8387, "Pictet-        
Spengler Reaction in
Trifluoroacetic Acid. Large Scale
Synthesis of         
Pyridoindolobenzodiazepine as
an Atypical Antipsychotic Agent."

Biao Jiang, Philip Ma, Synthetic
Communications, 1995, 25,
3641, "An         Improved
Synthesis of (+)-3,4-O-
Isopropylidene Butyne."

Lin-hua Zhang, Philip Ma, Tetra.
Lett., 1994, 35, 5765, "Facile
Detosylation of Cyclopeptides. An
Effective Synthesis of Platelet
Glycoprotein IIb/IIIa Inhibitors."

Zhang, Lin-Hua; Ma, Philip;
Degrado, William F., US
5811749, Oct., 1998, "Process
For the Preparation of
Cyclopeptide Platelet
Glycoprotein IIb/IIIa Inhibitors."        

Wong, P. C.; Ma, P.; et al., J.
Pharmacol. Exp. Ther., 1993, 265
(3), 1088,        "Pharmacology of 2-
amino-1,4-dihydro-4-(2-{4-[4-(2-
methoxyphenyl)-1-        piperazinyl]
butylsulfinyl}phenyl)-methyl-5-
notro-3-pyridine carboxylic
acid         methylester (XB513), a
novel calcium agonist with alpha-
1 adrenergic receptor         
antagonistic property."

Maurin, M. B.; Vickery, R. D.; Ma,
P.; Manalo, J.; Hussain, M. A.,
Pharm. Research, 9 (11), 1518,
1992, "Employing Ionization
Behaviors To Resolve A Trace-
Level Impurity: Determination Of
1,4-Dihydro-2,6-dimethyl-4-(3-
nitrophenyl)-3,5-
pyridinedicarboxylic Acid Di-2-
[methyl(phenylmethyl)amino]ethyl
Ester in Nicardipine Drug
Substance."

Aldrich, Paul E.; Earl, Richard A.;
Ma, Philip, WO9200741 A1, "2-
amino-1,4-dihydropyridine
derivatives with calcium agonist
and a-1 antagonist activity."

Osawa, E.; Imai, K.; Fujiyoshi-
Yoneda, T.; Jaime, C.; Ma, P.;
Masamune, S. Tetrahedron,
1991, 47, 4579, "On the
possibility of determining stereo-
chemistry in acyclic
polyhydroxylated compounds by
the combined vicinal coupling
constant/molecular mechanics
method. A test with alditol
peracetates."

Johnson, Alexander L.; Ma, Philip;
Timmermans, Petrus B.; Wexler,
Ruth R., EP         255710 A2,
1988, "Preparation of 1,4-
dihydropyridine derivatives with
calcium         agonist and alpha-1
antagonist activity."

Masamune, Satoru; Ma, Philip;
Moore, Richard E.; Fujiyoshi,
Teruyo; Jaime, Carlos; Osawa,
Eiji, J. Chem. Soc., Chem.
Comm., 1986, (3), 261,
"Computation of vicinal coupling
constants in tetra- and hexaalditol
peracetates using molecular
mechanics. A rational approach
to conformational analysis in
solution."

Masamune, Saturo; Ma, Philip;
Okumoto, Hiroshi; Ellingboe,
John W.; Ito,         Yukishige, J.
Org. Chem., 1984, 49, 2834,
"Synthesis of Amphotericin B.
1.         Fragment A of the aglycon."

Ma, P.; Martin, M. S.; Masamune,
S.; Sharpless, K. B.; Viti, S. M., J.
Org. Chem. 1982, 47, 1378,
"Synthesis of saccharides and
related polyhydroxylated natural
products. 2. Simple deoxyalditols."

Katsuki, T.; Lee, A. W. M.; Ma, P.;
Martin, V. S.; Masamune, S.;
Sharpless, K.         B.;
Tuddenham, D.; Walker, F. J., J.
Org. Chem., 1982, 47, 1373,
"Synthesis         of saccharides
and related polyhydroxylated
natural products. 1. Simple
alditols."

Choy, William; Ma, Philip;
Masamune Satoru, Tetra. Lett.,
1981, 22, 3555, "Enantioselective
synthesis of beta-
hydroxyisobutyric acid: a useful
synthon in the synthesis of
polypropionate-type natural
products."

Nicolaou, K. C.; Barnette, W. E.;
Ma, P., J. Org. Chem., 1980, 45,
1463, "A remarkably simple,
highly efficient, and
stereoselective synthesis of
steroids and other polycyclic
systems. Total synthesis of estra-
1,3,5(10)-trien-17-one via
intramolecular capture of o-
quinodimethanes generated by
cheletropic elimination of sulfur
dioxide."